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Buy 4-AcO-DMT , O-Since both psilocybin and acetylpsilocin are believed to be prodrugs of psilocin, David Nichols has suggested that acetylpsilocin, a synthetically produced psychoactive substance, could be a useful substitute for psilocybin in pharmacological research.

4-ACO-DMT is a synthetic psychedelic tryptamine often referred to as O-acetylpsilocin, 4-acetoxy-DMT or psilacetin. It is the lower homolog of 4-AcO-DET, 4-AcO-MiPT and 4-AcO-DiPT. It is the acetylated version of the psilocybin mushroom alkaloid psilocin. David Nichols has proposed the molecule as a potentially valuable substitute for psilocybin in pharmacological research, as both are considered prodrugs of psilocin.[Due to their structural similarities, psilocybin, psilocin and this chemical all have the same subjective profile of action.

claimed that they felt completely the same. This means that 4-AcO-DMT can serve as an ideal alternative to psilocybin mushrooms.

The first patent for 44-ACO-DMT and numerous other psilocin esters was granted on January 16, 1963 by Sandoz Ltd. through Albert Hofmann and Franz Troxler. However, 4-AcO-DMT is still classified as a psychedelic and had little use before it was made available on the Internet as a gray-zone substance for research purposes.

The partial agonistic activity of 4-ACO-DMT at the 5-HT2A receptor is thought to be responsible for some of its psychedelic effects. However, the function of these interactions and how they lead to the psychedelic experience is still poorly understood Buy 4-AcO-DMT.

Psilacetin, also known as 4-AcO-DMT, is thought to be deacetylated to psilocin in the body during first-pass metabolism and subsequent metabolic processes, as psilacetin is also active when administered via the liver. This is based on reports that most users are unable to distinguish between these two substances when ingested, so it is often assumed that they have similar subjective effects. However, it has not been scientifically confirmed.

Nevertheless, some people claim that the acetylated and non-acetylated versions of psilocin have subjectively different effects. While some users claim that it lasts much shorter than psilocin, others claim that it lasts significantly longer. In comparison to psilocin, many users experience less nausea and body fatigue. Some users note that 4-AcO-DMT causes visual distortions that are more similar to those caused by DMT than those caused by psilocin. These variations may occur when 4-AcO-DMT acts as a standalone drug and not just a prodrug.

Chemistry

4-aco-dmt or 4-acetoxy-n,n-dimethyltryptamine is a synthetic indole alkaloid molecule of the tryptamine chemical class. Tryptamines have a common core structure comprising a bicyclic indole heterocycle attached to a terminal amino group at r3 via an ethyl side chain.

4-Acodmt is substituted at r4 of its indole heterocycle with an acetoxy functional group (-aco) ch3coo-. It also contains two ch3- methyl groups attached to the terminal amine rn of the ethyl side chain.

4-Aco-dmt is the acetate ester analog of psilocin (4-Ho-dmt) and the n-substituted methyl homolog of 4-Aco-met. It is the o-acetylated form of psilocin, while psilocybin is the o-phosphorylated form.
Pharmacology

the psychedelic effects of 4-aco-dmt are thought to be due to its activity as a partial agonist for the 5-ht2a receptor. however, the role of these interactions and how they lead to the psychedelic experience is the subject of ongoing scientific investigation.

It is assumed that 4-Acodmt is deacetylated to psilocin in the body during first-pass metabolism, by the acidic conditions in the stomach and during passage through the liver.